TRANSLIFESCIENCES, expertise
My expertise
Expertise of translation techniques and terminology. Expertise of English. Use of documentaries and terminological resources. Collaboration with the translation subscribers. Evaluation of assistance tools for translation and terminology. Collaboration avec les demandeurs de traduction. Evaluation des outils d’aide à la traduction et à la terminologie.
My scientific path
Freelance Translator Biochemist Education ¨ Ph.D. in Biochemistry and Molecular Phytopathology (1996) ¨ DEA in Metabolic Biochemistry (1984) ¨ Master of Biochemistry, option in bacteriology and toxicology (1983) ¨ License in Cellular Physiology (1982) ¨ License in Biochemistry, option genetic and virology (1981) ¨ DEUG B , Life Sciences (1980) Experience Since 2006 Freelance translator. I started my own new business in translation and proof reading, specialized in life sciences. I’m currently looking for any business opportunities. I’m offering: Services – Translation of documents linked to scientific and technical usage. – Proofing of documents translated by internal team or contractors. – Perform prompt terminological or systematic searches. Competences – Expertise of technical translation and terminology. – Expertise of the use of documentaries and terminological resources. – Collaboration with translation subscribers. – Evaluation of assistance tools for translation and terminology. – Use of all available CAT tools 1989-2006 Lableader with Syngenta Crop Protection AG (formerly, Sandoz AG and Novartis AG). – Elucidation of new modes of action of molecules – Purification, discovery, selection and of new potential protein targets – Development of new enzymatic tests and their miniaturization – Purification of peptides and proteins for crystallography and High Throughput Screenings – Implementation of site directed High Throughput Screenings – Elucidation of Moa’s in cooperation with Chemistry of Structure-Activity Relationship Management of a research laboratory (up to 5 associate scientists): coordination of internal as well as external research projects. Integration of young scientists into the team (post-docs, DESS, post-graduates) Permanent formation of my team with updated techniques Create and lead a project – Proof of concept – setting the milestones for each member of my team – regular update of the SWOT’s – Defence of projects in decisional meetings – interdisciplinary teamwork Collaboration with Chemistry, Biology Bioinformatics, Health assessment and Regulatory affairs Project (IPD). Elucidation of biological activity of the PR-1 proteins and structure characterization in collaboration with Pr K.Wüthrich (ETH, Zurich ). In agreement with the company, this work allowed me to obtain a Ph.D. 1994-1995 One year exchange scientist in the US Research Centre (Palo-Alto). I worked on the purification of a new target for crop protection compounds and in the implementation of a toxicological assay. For my work, I received the 1995 Lumiere Award. 1987-1989 Two years as post-graduate with Ciba, under the supervision of Dr. H-P Schär and Dr. Scheidegger ( Basel ). – Implementation of enzymatic assays in amino acid biosynthesis – Screening of inhibitors – Purification to homogeneity and N-terminal sequencing of plant enzymes Technical Protein Biochemistry : FPLC, AKTA, Biacore, 2D electrophoresis, spectrophotometry, radiolabelling, enzymology, conventional and affinity chromatographic separations Computational analysis : BLAST, Vector Nti, Mascott Molecular Biology : cDNA bank genesis, Northern &Southern blots, PCR based cloning strategies, over-expression in heterologous systems Languages ¨ English : read, spoken, written ¨ German : read, spoken, written ¨ French : mother language Personal Development ¨ New England Biolabs workshop in molecular Biology and PCR (2001) ¨ Basic leadership training (2003) ¨ Situational leadership training (2003)
Documentation
Niderman T., Bruyère T., Gügler K. and Moesinger E. (1993). Antifungal activity of native and recombinant tomato P14 proteins. In : Mechanisms of plant defense responses. Bernard Fritig and Michel Legrand eds., Kluwer Academic Publishers, Dordrecht . p 450.
Niderman T., Bruyère T., Gügler K. and Moesinger E. (1993). Antifungal activity of native and recombinant tomato P14 proteins. 3 rd International Workshop on Pathogenesis-Related Proteins in Plants, Arolla , Switzerland , August 16-20.
Cohen Y., Gisi U. and Niderman T. (1993). Local and systemic protection against Phytophthora infestans induced in potato and tomato by jasmonic acid and jasmonic methyl ester.Phytopathol. 83, 1054-1062.
Bruyère T., Niderman T., Dolfini L. and Moesinger E. (1994). Cloning, transgenic expression and antifungal activity of the P14c protein: the most active member of tomato PR-1 family. 4 th International Congress of Plant Molecular Biology, Amsterdam , June 19-24.
Cohen Y., Niderman T., Moesinger E. and Fluhr R. (1994). ß-aminobutyric acid induces the accumulation of Pathogenesis-Related proteins in tomato (Lycopersicon esculentum L.) plants and resistance to late blight infection by Phytophthora infestans.Plant Physiol. 104, 59-66.
Cohen, Yigal; Guegler, Karl; Moesinger, Egon; Niderman, Thierry. Fungicidal proteins P14 of tomato; purification and cloning of sequences encoding them.. (Sandoz Ltd., Switz.; Sandoz-Patent-G.m.b.H.). PCT Int. Appl., 36 pp. CODEN: PIXXD2. WO 9220800 A1 921126. Designated States: W: JP , US . Designated States: RW: AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, MC, NL, SE. Patent written in English. Application: WO 92-EP1063 920514. Priority: GB 91-10544 910515 CAN 118:98287
Niderman T., Genetet I., Bruyère T., Gees R., Stinzi A., Legrand M., Fritig B. and Moesinger E. (1995). Pathogenesis-Related PR-1 proteins are antifungal : isolation and characterization of three kilodalton proteins of tomato and of a basic PR-1 of tobacco with inhibitory activity against Phytophthora infestans. Plant Physiol. 108, 17-27
Niderman T. (1996).: Induction of defense responses in tomato : search for chemical elicitors, study of the function of the signaling molecule, jasmonate, and identification of PR-proteins (Pathogenesis-Related) with antimicrobial activities toward Phytophthora infestans. Ph.D
Siehl D., Subramanian M., Scheuerman R., Walters E., Niderman T. (1996). Prospecting for herbicidal inhibitors of aromatic amino acid biosynthesis. Weed Science Society of America Meeting.Vol 36, A320 .
Siehl D., Subramanian M., Walters E., Blanding J., Niderman T., Weinmann C. (1997). Evaluating anthranilate synthase as a herbicide target. Weed Sci. 45(5), 628-633
Walters E.W., Lee S.F., Niderman T., Bernasconi P., Subramanian M.V. and Siehl D. (1997). Adenylosuccinate synthase from maize. Purification, properties and mechanism of inhibition by 5’-phosphohydantocidin. Plant Physiol. 114, 549-555.
Niderman T. (2000). Inhibitory activity of metabolite CGA 195’660 against ALS enzyme in Zea mays. Review report for the active substance triasulfuron. Annex I of Directive 91/414/EEC
Wenger Jean and Niderman Thierry. (2007). Acetyl-CoA carboxylase inhibitors. In Modern Crop Protection Compounds. Schirmer U. and Kraemer W. eds. Wiley VCH publishers. 335-358.
Muehlebach M., Brunner H-G., Cederbaum F., Maetzke T., Mutti R., Schnyder A., Stoller A., Wendeborn S., Wenger J., , Boutsalis P., Cornes D., Friedmann A.A., Glock J., Hofer U., Hole S., Niderman T., Quadranti M. (2007). Discovery and SAR of Pinoxaden: A New Broad Spectrum, Postemergence Cereal Herbicide. In Pesticide Chemistry. Ohkawa, H. Miyagawa, H. Lee, P. Wiley-VCH, publishers. 101-109.
Glock J., Allen J., , Niderman T., Haas H-U., Chollet R., ,Eberle M., Renold P., Lutz W., Ehrler J., Valentini M., Walti M., Sieger E., Vettiger T., Brunner H., Penzotti J.E., Grootenhuis P.D.J., Bondy S., Corner D.D., Cheng S., Steiger A., Zeller ., Laue G., Friedmann A., Jacob O., Nina M., Widmer H-J., Kreuz K., Craig G.W . (2008). Lead-Discovery of bis-Aromatic Alkynes, A Novel Class of Herbicides.Chimia. 62, 23-28.
Muehlebach M., Boeger M., Cederbaum F., Cornes D., Friedmann A A., Glock J., Niderman T., Stoller A and Wagner T. (2009). Aryldiones incorporating a [1,4,5]oxadiazepane ring. Part I: Discovery of the novel cereal herbicide pinoxaden. Bioorganic & Medicinal Chemistry 17 (2009), pp. 4241-4256.
Réalisation & référencement
